Reaction time and clicks-per-second tests.
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Two quick tests: a reaction-time test that measures how fast you click after the screen turns green, and a five-second clicks-per-second (CPS) test.
Many people land between about 200 and 300 ms. Results vary with your screen, mouse and device, so compare with your own best.
Yes. Screen refresh rate, mouse or touch latency and browser load all add a little delay, so avoid comparing across different devices.